The average asking price for a used 2021 Mercedes-Benz E 350 is $29,391, with 49,918 miles on average, across 122 cars for sale at U.S. dealers as of Nov 10, 2026.
| State | Average asking | Average miles | For sale | Days listed |
|---|---|---|---|---|
| California | $27,849 | 55,148 | 19 | 41 |
| Florida | $29,206 | 42,901 | 14 | 47 |
| Texas | $26,905 | 55,989 | 14 | 60 |
| Georgia | $28,982 | 50,599 | 11 | 81 |
| Illinois | $29,852 | 54,382 | 7 | 54 |
| New York | $28,502 | 47,296 | 7 | 54 |
| Ohio | $27,034 | 74,054 | 6 | 55 |
| Virginia | $24,708 | 58,733 | 5 | 96 |
| New Jersey | $34,504 |
Used 2021 Mercedes-Benz E 350s for sale at U.S. dealers ask $29,391 on average (half ask less than $28,974), across 122 cars. The cars for sale have 49,918 miles on average: one with fewer miles is worth more, and one with more is worth less. To check one car's price against cars of its trim and mileage, enter its VIN in OttoQuest's free Deal Check.
Among states with at least 10 for sale, Texas has the lowest average asking price, $26,905 across 14 cars with 55,989 miles on average, and Florida the highest, $29,206 across 14 with 42,901 miles on average. Part of a gap between states is mileage and trim, not the state.
The 122 for sale with a listing date have been listed 63 days on average. A car listed much longer than that, or one whose price has already been cut, usually leaves more room to negotiate.
The 2021 asks $29,391 on average with 49,918 miles; the 2020 asks $24,863 with 57,574 miles, and the 2022 asks $33,406 with 41,196 miles.
NHTSA lists 12 safety recall campaigns that cover the 2021 Mercedes-Benz E 350. Repairs are free at a dealer of the make; check a car's VIN with NHTSA before you buy to see whether its recalls were fixed.
Used and certified cars for sale at US dealers, each car counted once. Days listed are the dealer’s own days on market where they publish it. Price moves compare the same cars at both ends of the window.
| 33,347 |
| 5 |
| 111 |
| Year | Average asking | Miles | For sale |
|---|---|---|---|
| 2027 | $73,202 | 494 | 25 |
| 2026 | $64,623 | 5,263 | 343 |
| 2025 | $50,558 | 17,582 | 119 |
| 2024 | $50,596 | 19,158 | 125 |
| 2023 | $40,603 | 29,568 | 403 |
| 2022 | $33,406 | 41,196 | 125 |
| 2021 | $29,391 | 49,918 | 122 |
| 2020 | $24,863 | 57,574 | 127 |
| 2016 | $14,097 | 103,019 | 116 |
| 2015 | $13,562 | 102,227 | 63 |
| 2014 | $12,376 | 104,752 | 294 |
| 2013 | $11,423 | 100,663 | 122 |
| 2012 | $11,380 | 103,409 | 97 |
| 2011 | $9,598 | 105,774 | 100 |
| 2010 | $9,437 | 105,733 | 67 |
| 2009 | $8,337 | 119,530 | 18 |
| 2008 | $7,276 | 124,259 | 34 |
| 2007 | $6,910 | 110,195 | 36 |
| 2006 | $6,152 | 122,252 | 19 |
