The average asking price for a used 2021 Mercedes-Benz E 450 is $39,488, with 44,355 miles on average, across 49 cars for sale at U.S. dealers as of Nov 10, 2026.
| State | Average asking | Average miles | For sale | Days listed |
|---|---|---|---|---|
| New Jersey | $37,293 | 51,566 | 10 | 49 |
| Florida | $45,555 | 28,718 | 8 | 17 |
Used 2021 Mercedes-Benz E 450s for sale at U.S. dealers ask $39,488 on average (half ask less than $39,549), across 49 cars. The cars for sale have 44,355 miles on average: one with fewer miles is worth more, and one with more is worth less. To check one car's price against cars of its trim and mileage, enter its VIN in OttoQuest's free Deal Check.
The 48 for sale with a listing date have been listed 37 days on average. A car listed much longer than that, or one whose price has already been cut, usually leaves more room to negotiate.
The 2021 asks $39,488 on average with 44,355 miles; the 2020 asks $31,549 with 58,700 miles, and the 2022 asks $44,373 with 38,952 miles.
NHTSA lists 14 safety recall campaigns that cover the 2021 Mercedes-Benz E 450. Repairs are free at a dealer of the make; check a car's VIN with NHTSA before you buy to see whether its recalls were fixed.
Used and certified cars for sale at US dealers, each car counted once. Days listed are the dealer’s own days on market where they publish it. Price moves compare the same cars at both ends of the window.
| 44,355 |
| 49 |
| 2020 | $31,549 | 58,700 | 69 |
| 2019 | $28,965 | 63,909 | 82 |
