The average asking price for a used 2021 Mercedes-Benz S 580 is $60,118, with 44,565 miles on average, across 4 cars for sale at U.S. dealers as of Nov 10, 2026.
Used 2021 Mercedes-Benz S 580s for sale at U.S. dealers ask $60,118 on average (half ask less than $60,749), across 4 cars. The cars for sale have 44,565 miles on average: one with fewer miles is worth more, and one with more is worth less. To check one car's price against cars of its trim and mileage, enter its VIN in OttoQuest's free Deal Check.
The 2021 asks $60,118 on average with 44,565 miles; the 2022 asks $68,151 with 28,992 miles.
NHTSA lists 16 safety recall campaigns that cover the 2021 Mercedes-Benz S 580. Repairs are free at a dealer of the make; check a car's VIN with NHTSA before you buy to see whether its recalls were fixed.
Used and certified cars for sale at US dealers, each car counted once. Days listed are the dealer’s own days on market where they publish it. Price moves compare the same cars at both ends of the window.
